ImmunoPath

Immunotherapy decision-support pipeline for predicting immune biomarkers from H&E slides using MedGemma and related medical foundation models.

ImmunoPath is a clinical decision-support pipeline for predicting immune biomarkers directly from routine H&E histopathology slides.

  • Combined MedGemma, TxGemma, Path Foundation, and MedSigLIP to predict 8 immune biomarkers.
  • Curated 60,396 patches across 950 TCGA NSCLC patients and selected 7,574 diverse patches via K-Means.
  • Fine-tuned a 4B vision-language model with LoRA on A100-SXM4-80GB GPUs.
  • Improved structured prediction reliability to 100% JSON/schema compliance and reduced TIL MAE to 0.16 on 94 held-out patients.

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